| “Specialist Separations for the Pharmaceutical and Fine Chemical Industries” |
Membrane Extraction Technology
Unit 25 Talina Centre
Bagleys Lane, Fulham
London, SW6 2BW
United Kingdom
Phone:
+44 (0) 20 7751 3153
Fax:
+44 (0) 20 7751 3154
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All our laboratory equipment is pressure-rated up to 69 bar (1000 psig), conforms to the Pressure Equipment Directive 97/23/EC, and is certified leak-free. Our nanofiltration equipment ranges from laboratory scale (METcell and combined METcell with METcell CrossFlow System) to pilot unit (OSN pilot plant).
System Description
This is a small dead-end cell housing flat membrane sheets which is specifically designed to carry out membrane separations at the lab scale. The equipment is easy and efficient to operate, requiring only small solution volumes (up to 270 ml), featuring a wide membrane surface area, and giving excellent solution stirring close to the membrane surface. The METcell can be used in batch or semi-continuous processing. The cell is completely made of stainless steel, and can be safely used with a large variety of aqueous and non-aqueous solvents.
For more information please visit our METcell page or Ask us.
Also see the METcell with METcell CrossFlow System - MET's new product combines the deadend filtration METcell with the added CrossFow.
The METcell is a stainless steel (for particularly aggressive environments please ask us for Hastelloy C276 pressure equipment), high-pressure stirred cell and is suitable for reverse osmosis (RO) and nanofiltration (NF) separations using aqueous and non-aqueous solvents. The MET Gas unit is supplied with the METcell to allow simple connection to a gas cylinder. All components of the assembled system are pressure rated to 69 bar (1000 psig).
Technical Specification
Operating Parameters
| Membrane Size |
90 mm diameter (area = 63.6 cm2) |
| Active Membrane Size |
80.8 mm diameter (area = 51.4 cm2) |
| Processable Volume |
500 mL |
| Hold-up Volume |
~ 5 mL |
| Maximum Pressure |
69 bar (1000 psig) |
| Maximum Temperature |
The lower of 50 °C or the temperature at which the vapour pressure of the solvent exceeds 1.5 bar absolute. |
| Material Compatibility |
The material is tolerant to all aqueous and organic solvents compatible with 316 stainless steel (ss) and FEP. (for particularly aggressive environments please ask us for Hastelloy C276 pressure equipment) |
Connections
| Permeate Outlet |
1/8 ” diameter 316 SS Tubing |
| Pressure Inlet |
1/4 ” NPT (female) |
| Feed Inlet |
1/4 ” NPT (female) |
Wetted Materials
| Cell Body |
316 Stainless Steel or Hastelloy C276 |
| O-rings |
FEP and Viton |
| Gaskets |
Viton |
| Stirrer Bar |
PTFE coated magnet with 316 SS (or Hastelloy C276) support arms |
Dimensions
| Cell Diameter |
64 mm, flaring to 120 mm |
| Cell Height |
171 mm (including additional height of reinforced cell top) |
MET Gas Unit
| Gas Unit frame Pressure relief spring kit |
316 Stainless Steel |
| Isolation valve |
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| Vent Valve |
1/4" O.D. tube Pressure regulator: 0 - 69 bar g |
| Discharge |
1/4" O.D. hose (supplied) |
| Pressure Gauges |
Supplied (to display supply pressure and METcell pressure) |
| Pipework Kit |
Supplied (comprising of tubing, elbow, tees and union) |
Features
The key design features are described below:
- The METcell is designed to meet the European Pressure Directive requirements, and the materials of construction are in compliance with FDA current good manufacturing practice (cGMP).
- Easy-to-use design, with easily removable top to charge feed solution, and easily removable base for membrane replacement.
- Safe operation up to 69 bar with high pressure mechanical couplings (ASME BPE 1997 compliant) and seals, enabling RO and NF separations to be carried out.
- Provision of fittings for connection to a pressure source (gas cylinder-recommended).
- Pre-assembled MET Gas unit including an isolation valve, vent valve, pressure regulator, pressure relief valve, and pressure gauges to allow safe and simple operation of a high pressure system.
- Connection port for an HPLC pump, allowing charging of solutions into the METcell without opening the cell, particularly useful when solutes are oxygen/moisture sensitive or when continuous operation is required, e.g. permeate recycle.
- A 35mm-wide removable PTFE coated stirrer bar is used to promote excellent mixing down to low liquid volume holdups.
- All components can be sterilized or autoclaved as part of a cleaning procedure.
- The METcell can house membrane disks with diameter between 90 and 93 mm. A4 sheets from the STARMEMTM range of solvent nanofiltration membranes are available with molecular weight cut-offs (MWCOs) between 200 and 400 Dalton's.
- Processing times will vary depending on membrane flux. As an indication, with a STARMEMTM membrane in methanol, giving a flux of 100 Lm-2h-1, a METcell would process 100 ml in approximately 12 minutes.
A comprehensive instruction manual in paper and electronic format is supplied with each METcell.
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