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Purification of target molecules from post reaction streams is a common problem. Large molecules, such as dimers/trimers or
colour bodies may need to be separated from a lower molecular
weight API; alternatively smaller molecules, such as unreacted
reaction reagents or reaction by-products, may need to be
separated from an API of higher molecular weight.
MET’s product purification technology employs Organic Solvent Nanofiltration
(OSN) to provide efficient, rapid, and economical purifications.
MET’s product purification technology achieves up to 99% isolation
of the target molecule, in less time, and without the significant
cost, or yield penalties, associated with chromatography.
So,
- If you want to rapidly separate your API from higher MWcontaminants, or lower MW species ...
- If you’re fed up with costly and lengthy chromatography
processes …
… couple MET’s product purification technology to your
MET Product Purification technology used in monomer / dimer separation
- Separations of monomers and dimer / trimer by-products are commonly achieved by chromatographic methods but at a significant yield and cost penalty
- OSN offers a much more efficient separation pathway resulting in a faster throughput,
better scalability, and with a lower yield penalty.
- Example: Using STARMEM™ 120 at 60 bar, a permeate stream with 99.2 % monomer
purity was obtained, with 90.8 % yield recovery of monomer fed to the system
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